Our research group Chromosome Dynamics studies the relationships between histone modification, 3D genome organization and regulation of gene expression.
Chromosome Dynamics
Based in the Institute of Plant Sciences of Paris-Saclay and part of the Developmental Genetics and Genomics (DGG) department, Chromosome Dynamics’ research group focuses its work in eukaryotes, nuclear DNA is organized in chromatin.
“We strongly believe that understanding the spatial organization of the genome in the nucleus, as well as its functional implications, will become a fundamental quest in the post-genomic era, as this will allow integration of our knowledge on the linear genome with molecular regulatory networks and phenotypic data”
Both the temporal and spatial expression of genomes is influenced by chromatin topology, which is governed by conserved processes. These mechanisms have been implicated in numerous adaptations, including the response to biotic and abiotic stresses as well as in developmental programs. But they are still many open questions that we are tackling now: What determine chromatin architecture? How are promoter-enhancer contacts established in plants? How are these contacts established and released over time? What is the function of TFs in promoter-enhancer contact formation and or stability? What are the molecular mechanisms behind it?
In this context to answer those questions we use genetics, genomics and epigenomics approaches.